InnateDB Protein
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IDBP-249307.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ufd1l
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Protein Name
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ubiquitin fusion degradation 1 like
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Synonyms
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Ufd1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000111241
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InnateDB Gene
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IDBG-142494 (Ufd1l)
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Protein Structure
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Function |
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). It may be involved in the development of some ectoderm-derived structures. {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 57 interaction(s) predicted by orthology.
Experimentally validated |
Total |
8
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
57 [view]
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Molecular Function |
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Biological Process |
GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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Cellular Component |
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PDB ID |
MGI:109353
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InterPro |
IPR004854
Ubiquitin fusion degradation protein UFD1
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PFAM |
PF03152
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P70362
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PhosphoSite |
PhosphoSite-P70362
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22230
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UniGene |
Mm.487938
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RefSeq |
XP_006522068
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MGI ID |
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MGI Symbol |
Ufd1l
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OMIM |
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CCDS |
CCDS28028
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HPRD |
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IMGT |
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EMBL |
AK147138
AK169062
BC006630
CH466521
U64445
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GenPept |
AAD08719
AAH06630
BAE27708
BAE40849
EDK97535
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