InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgce

Summary

InnateDB Protein

IDBP-249315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgce

Protein Name

sarcoglycan, epsilon

Synonyms

e-SG;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111240

InnateDB Gene

IDBG-127960 (Sgce)

Protein Structure

UniProt Annotation

Function

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.

Subcellular Localization

Cell membrane, sarcolemma {ECO:0000269PubMed:17200151}; Single-pass membrane protein {ECO:0000269PubMed:17200151}. Golgi apparatus {ECO:0000269PubMed:17200151}. Cell projection, dendrite {ECO:0000269PubMed:17200151}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Identified in all tissues tested. Expression highest in lung and placenta, moderate in brain, heart and skeletal muscle, low in kidney and liver. Also detected in embryo.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

Cellular Component

GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016012	sarcoglycan complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0032590	dendrite membrane
GO:0042383	sarcolemma