InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nr3c1

Summary

InnateDB Protein

IDBP-249335.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Nr3c1

Protein Name

nuclear receptor subfamily 3, group C, member 1

Synonyms

GR; Grl-1; Grl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111229

InnateDB Gene

IDBG-142259 (Nr3c1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 180 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	180 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004883	glucocorticoid receptor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006111	regulation of gluconeogenesis
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008211	glucocorticoid metabolic process
GO:0030325	adrenal gland development
GO:0031946	regulation of glucocorticoid biosynthetic process
GO:0042921	glucocorticoid receptor signaling pathway
GO:0043401	steroid hormone mediated signaling pathway
GO:0043402	glucocorticoid mediated signaling pathway
GO:0043525	positive regulation of neuron apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0060603	mammary gland duct morphogenesis
GO:1900170	negative regulation of glucocorticoid mediated signaling pathway

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:95824

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001409 Glucocorticoid receptor
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF02155
PF00105

PRINTS

PR00528
PR00047
PR00398

PIRSF

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt