Version 5.4
Mus musculus Protein: Ica1
Summary
InnateDB Protein IDBP-249441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ica1
Protein Name islet cell autoantigen 1
Synonyms 69kDa; ICA69;
Species Mus musculus
Ensembl Protein ENSMUSP00000111182
InnateDB Gene IDBG-128452 (Ica1)
Protein Structure
UniProt Annotation
Function May play a role in neurotransmitter secretion. {ECO:0000303PubMed:11029035}.
Subcellular Localization Cytoplasm, cytosol {ECO:0000269PubMed:11029035}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.
Disease Associations
Tissue Specificity Predominantly expressed in brain, pancreas and stomach mucosa. High expression also found in stomach muscle and testis. {ECO:0000269PubMed:11029035}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0019904 protein domain specific binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0046928 regulation of neurotransmitter secretion
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030054 cell junction
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0030672 synaptic vesicle membrane
Protein Structure and Domains
PDB ID MGI:96391
InterPro IPR006723 Islet cell autoantigen Ica1, C-terminal
IPR010504 Arfaptin homology (AH) domain
PFAM PF04629
PF06456
PRINTS
PIRSF
SMART SM01015
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97411
PhosphoSite PhosphoSite-
TrEMBL D3Z699
UniProt Splice Variant
Entrez Gene 15893
UniGene Mm.275683
RefSeq XP_006505057
MGI ID
MGI Symbol Ica1
OMIM
CCDS CCDS19911
HPRD
IMGT
EMBL AC158670 BC002030 U26459 U26460 U26461 U34595 U37013 U37014 U37015 U37082 U37083 U37084 U37085 U37086 U37184 U37185 U37186
GenPept AAB19182 AAB40939 AAC52992 AAC52993 AAC99989 AAH02030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca