Version 5.4
Mus musculus Gene: Ica1
Summary
InnateDB Gene IDBG-128452.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ica1
Gene Name islet cell autoantigen 1
Synonyms 69kDa; ICA69
Species Mus musculus
Ensembl Gene ENSMUSG00000062995
Encoded Proteins
IDBP-128454
islet cell autoantigen 1
IDBP-249441
islet cell autoantigen 1
IDBP-249443
islet cell autoantigen 1
IDBP-249445
islet cell autoantigen 1
IDBP-787850
islet cell autoantigen 1
IDBP-537011
islet cell autoantigen 1
IDBP-536677
islet cell autoantigen 1
IDBP-532276
islet cell autoantigen 1
IDBP-538108
islet cell autoantigen 1
IDBP-542175
islet cell autoantigen 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003147:
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren\'s syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:8630527-8778488
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000038403 ENSMUSP00000040062
ENSMUST00000115520 ENSMUSP00000111182
ENSMUST00000115519 ENSMUSP00000111181
ENSMUST00000115518 ENSMUSP00000111180
ENSMUST00000156695 ENSMUSP00000138459
ENSMUST00000145870
ENSMUST00000153390 ENSMUSP00000117734
ENSMUST00000127398 ENSMUSP00000118194
ENSMUST00000126430 ENSMUSP00000116861
ENSMUST00000135113
ENSMUST00000126039 ENSMUSP00000118010
ENSMUST00000151758 ENSMUSP00000117112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0019904 protein domain specific binding
Biological Process
GO:0006836 neurotransmitter transport
GO:0046928 regulation of neurotransmitter secretion
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005829 cytosol
GO:0030054 cell junction
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0030672 synaptic vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000003147
View Gene Order
ENSBTAG00000000799
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04940
Type I diabetes mellitus pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04940
Type I diabetes mellitus pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z020 D3Z118 D3Z376 D3Z699
UniProt Splice Variant
Entrez Gene 15893
UniGene Mm.275683
RefSeq NM_001252266 NM_010492 XM_006504993
OMIM
CCDS CCDS19911
HPRD
IMGT
MGI ID MGI:96391
MGI Symbol Ica1
EMBL AC158670
GenPept
RNA Seq Atlas 15893

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca