InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ece2

Summary

InnateDB Protein

IDBP-249451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ece2

Protein Name

endothelin converting enzyme 2

Synonyms

1810009K13Rik; 6330509A19Rik; 9630025D12Rik; BB127715;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111184

InnateDB Gene

IDBG-145195 (Ece2)

Protein Structure

UniProt Annotation

Function

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. {ECO:0000269PubMed:12464614}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasmic granule membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed at high levels in central nervous system. Expressed in adrenal glands, ovary and uterus, and at low levels in heart. {ECO:0000269PubMed:10811845}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008168	methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006508	proteolysis
GO:0007420	brain development
GO:0007507	heart development
GO:0008152	metabolic process
GO:0010002	cardioblast differentiation
GO:0016486	peptide hormone processing
GO:0032259	methylation