Version 5.4
Mus musculus Gene: Ece2
Summary
InnateDB Gene IDBG-145195.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ece2
Gene Name endothelin converting enzyme 2
Synonyms 1810009K13Rik; 6330509A19Rik; 9630025D12Rik; BB127715
Species Mus musculus
Ensembl Gene ENSMUSG00000022842
Encoded Proteins
IDBP-145201
endothelin converting enzyme 2
IDBP-145203
endothelin converting enzyme 2
IDBP-249451
endothelin converting enzyme 2
IDBP-401469
endothelin converting enzyme 2
IDBP-401467
endothelin converting enzyme 2
IDBP-401464
endothelin converting enzyme 2
IDBP-542962
endothelin converting enzyme 2
IDBP-542964
endothelin converting enzyme 2
IDBP-542965
endothelin converting enzyme 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145194:
Endothelin-converting enzymes, such as ECE2 (EC 3.4.24.71), are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family (Lorenzo et al., 2001 [PubMed 11718899]).[supplied by OMIM, Mar 2008]
This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:20611593-20646485
Strand Forward strand
Band B1
Transcripts
ENSMUST00000079600 ENSMUSP00000078550
ENSMUST00000003898 ENSMUSP00000003898
ENSMUST00000115522 ENSMUSP00000111184
ENSMUST00000120394 ENSMUSP00000113475
ENSMUST00000119224 ENSMUSP00000113772
ENSMUST00000122306 ENSMUSP00000114039
ENSMUST00000147849 ENSMUSP00000121231
ENSMUST00000152246
ENSMUST00000133344 ENSMUSP00000119693
ENSMUST00000145511
ENSMUST00000125971 ENSMUSP00000120239
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008168 methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007420 brain development
GO:0007507 heart development
GO:0008152 metabolic process
GO:0010002 cardioblast differentiation
GO:0016486 peptide hormone processing
GO:0032259 methylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
GO:0030659 cytoplasmic vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145194
View Gene Order
ENSBTAG00000005658
Not yet available
Cross-References
SwissProt Q80Z60
TrEMBL
UniProt Splice Variant
Entrez Gene 107522
UniGene Mm.263319
RefSeq NM_025462 NM_139293 NM_177940 NM_177941 NM_177942 XM_006521692 XM_006521697
OMIM
CCDS CCDS37290 CCDS28052 CCDS49793 CCDS49794 CCDS49796
HPRD
IMGT
MGI ID MGI:1101356
MGI Symbol Ece2
EMBL AF489569 AF489570 AK007407 AK007791 BC115541
GenPept AAI15542 AAO72356 AAO72357 BAB25019 BAB25257
RNA Seq Atlas 107522

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca