Version 5.4
Homo sapiens Protein: NAAA
Summary
InnateDB Protein IDBP-24961.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAAA
Protein Name N-acylethanolamine acid amidase
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000286733
InnateDB Gene IDBG-24959 (NAAA)
Protein Structure
UniProt Annotation
Function Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N- palmitoylethanolamine > N-myristoylethanolamine > N- lauroylethanolamine = N-stearoylethanolamine > N- arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N- lauroylsphingosine and N-palmitoylsphingosine. {ECO:0000269PubMed:15655246}.
Subcellular Localization Lysosome {ECO:0000305PubMed:10610717, ECO:0000305PubMed:15655246}.
Disease Associations
Tissue Specificity Expressed in numerous tissues, with highest levels in liver and kidney, followed by pancreas. {ECO:0000269PubMed:10610717}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008134 transcription factor binding
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
Biological Process
GO:0006629 lipid metabolic process
GO:0008150 biological_process
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR016699 Acid ceramidase-like
IPR029055 Nucleophile aminohydrolases, N-terminal
IPR029132 Choloylglycine hydrolase/NAAA C-terminal
PFAM PF02275
PRINTS
PIRSF PIRSF017632
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q02083
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 27163
UniGene Hs.437365
RefSeq NP_055250
HUGO HGNC:736
OMIM 607469
CCDS CCDS43239
HPRD 12122
IMGT
EMBL AB161353 BC006388 BC011854 M92449
GenPept AAA60119 AAH06388 BAD88528

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca