InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Thpo

Summary

InnateDB Protein

IDBP-249652.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Thpo

Protein Name

thrombopoietin

Synonyms

Mgdf; Ml; Mpllg; Tpo;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111097

InnateDB Gene

IDBG-146337 (Thpo)

Protein Structure

UniProt Annotation

Function

Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Found mainly in the liver, kidney and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005179	hormone activity

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0008283	cell proliferation
GO:0030099	myeloid cell differentiation
GO:0038163	thrombopoietin-mediated signaling pathway
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade