Version 5.4
Mus musculus Gene: Thpo
Summary
InnateDB Gene IDBG-146337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Thpo
Gene Name thrombopoietin
Synonyms Mgdf; Ml; Mpllg; Tpo
Species Mus musculus
Ensembl Gene ENSMUSG00000022847
Encoded Proteins
IDBP-146339
thrombopoietin
IDBP-249652
thrombopoietin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:20725158-20734511
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000076422 ENSMUSP00000075756
ENSMUST00000115437 ENSMUSP00000111097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005179 hormone activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0008283 cell proliferation
GO:0030099 myeloid cell differentiation
GO:0038163 thrombopoietin-mediated signaling pathway
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0051897 positive regulation of protein kinase B signaling
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000090534
View Gene Order
ENSBTAG00000000476
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_249309
Platelet Aggregation (Plug Formation) pathway
KEGG
mmu04640
Hematopoietic cell lineage pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
TPO signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_278
Platelet Aggregation (Plug Formation) pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_604
Hemostasis pathway
KEGG
hsa04640
Hematopoietic cell lineage pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
TPO signaling pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3943
RefSeq NM_001173505 NM_001289894 NM_009379 XM_006521984 XM_006521985 XM_006521986 XM_006521987
OMIM
CCDS CCDS37292
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca