InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdk16

Summary

InnateDB Protein

IDBP-249805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdk16

Protein Name

cyclin-dependent kinase 16

Synonyms

Crk5; Pctaire1; Pctk1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000111021

InnateDB Gene

IDBG-135033 (Cdk16)

Protein Structure

UniProt Annotation

Function

Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Can phosphorylate CCNY at 'Ser-336' (in vitro) (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. {ECO:0000250, ECO:0000269PubMed:16461345, ECO:0000269PubMed:21335063, ECO:0000269PubMed:22184064, ECO:0000269PubMed:22798068}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in testis and brain, and detected at lower levels in heart, skeletal muscle, adipose tissue, lung, spleen and pancreas (at protein level). Ubiquitous with highest levels in testis and brain, with longer form predominant in all tissues except the testis. {ECO:0000269PubMed:22184064, ECO:0000269PubMed:22796189, ECO:0000269PubMed:22798068}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004693	cyclin-dependent protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006887	exocytosis
GO:0007049	cell cycle
GO:0007283	spermatogenesis
GO:0030252	growth hormone secretion
GO:0031175	neuron projection development
GO:0061178	regulation of insulin secretion involved in cellular response to glucose stimulus

Cellular Component

GO:0008021	synaptic vesicle
GO:0030054	cell junction
GO:0030133	transport vesicle
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:97516

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt