Version 5.4
Mus musculus Protein: Eif4a2
Summary
InnateDB Protein IDBP-249843.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif4a2
Protein Name eukaryotic translation initiation factor 4A2
Synonyms 4833432N07Rik; BM-010; Ddx2b; eIF-4A-II; Eif4; eIF4A-II;
Species Mus musculus
Ensembl Protein ENSMUSP00000110998
InnateDB Gene IDBG-149304 (Eif4a2)
Protein Structure
UniProt Annotation
Function ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 51 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003743 translation initiation factor activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006413 translational initiation
Cellular Component
Protein Structure and Domains
PDB ID MGI:106906
InterPro IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014014 RNA helicase, DEAD-box type, Q motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00271
PF00270
PRINTS
PIRSF
SMART SM00490
SM00487
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10630
PhosphoSite PhosphoSite-P10630
TrEMBL
UniProt Splice Variant
Entrez Gene 13682
UniGene Mm.485605
RefSeq
MGI ID
MGI Symbol Eif4a2
OMIM
CCDS
HPRD
IMGT
EMBL AK076509 U64706 X12507 X14422 X56953
GenPept AAC53180 BAC36372 CAA31025 CAA32585 CAA40268 CAA40269

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca