Mus musculus Gene: Eif4a2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-149304.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Eif4a2 | ||||||||||||||||||||||
Gene Name | eukaryotic translation initiation factor 4A2 | ||||||||||||||||||||||
Synonyms | 4833432N07Rik; BM-010; Ddx2b; eIF-4A-II; Eif4; eIF4A-II | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000022884 | ||||||||||||||||||||||
Encoded Proteins |
eukaryotic translation initiation factor 4A2
eukaryotic translation initiation factor 4A2
eukaryotic translation initiation factor 4A2
eukaryotic translation initiation factor 4A2
eukaryotic translation initiation factor 4A2
eukaryotic translation initiation factor 4A2
eukaryotic translation initiation factor 4A2
eukaryotic translation initiation factor 4A2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156976:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Small nucleolar RNAs (snoRNAs) are small noncoding RNAs involved in RNA processing. Box H/ACA snoRNAs, such as SNORA81, direct the conversion of uridine to pseudouridine at specific residues of ribosomal RNAs or small nuclear RNAs (snRNAs) (Gu et al., 2005).[supplied by OMIM, Mar 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 16:23107444-23114136 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | B1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Cytokine Signaling in Immune system pathway
Deadenylation of mRNA pathway
Translation pathway
Antiviral mechanism by IFN-stimulated genes pathway
ISG15 antiviral mechanism pathway
Immune System pathway
Translation initiation complex formation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Initiation pathway
Interferon Signaling pathway
Gene Expression pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Ribosomal scanning and start codon recognition pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Deadenylation-dependent mRNA decay pathway
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KEGG |
RNA transport pathway
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INOH |
Insulin receptor signaling pathway
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PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
ISG15 antiviral mechanism pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Deadenylation of mRNA pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Translation initiation complex formation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Ribosomal scanning and start codon recognition pathway
Eukaryotic Translation Initiation pathway
Deadenylation-dependent mRNA decay pathway
Antiviral mechanism by IFN-stimulated genes pathway
Cytokine Signaling in Immune system pathway
Translation pathway
Interferon Signaling pathway
Metabolism of proteins pathway
Immune System pathway
Cap-dependent Translation Initiation pathway
Gene Expression pathway
Deadenylation of mRNA pathway
ISG15 antiviral mechanism pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Cytokine Signaling in Immune system pathway
Gene Expression pathway
Eukaryotic Translation Initiation pathway
Cap-dependent Translation Initiation pathway
Immune System pathway
Antiviral mechanism by IFN-stimulated genes pathway
Translation pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Metabolism of proteins pathway
Interferon Signaling pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Translation initiation complex formation pathway
Deadenylation-dependent mRNA decay pathway
Ribosomal scanning and start codon recognition pathway
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KEGG |
RNA transport pathway
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INOH |
Insulin receptor signaling pathway
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PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | D6RJ60 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 13682 | ||||||||||||||||||||||
UniGene | Mm.260084 Mm.431565 Mm.485605 | ||||||||||||||||||||||
RefSeq | NM_001123037 NM_001123038 NM_013506 XM_006521783 XM_006521784 XM_006521785 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS28074 CCDS49805 CCDS49806 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:106906 | ||||||||||||||||||||||
MGI Symbol | Eif4a2 | ||||||||||||||||||||||
EMBL | AC154540 CH466521 | ||||||||||||||||||||||
GenPept | EDK97659 | ||||||||||||||||||||||
RNA Seq Atlas | 13682 | ||||||||||||||||||||||