InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pot1a

Summary

InnateDB Protein

IDBP-249873.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pot1a

Protein Name

protection of telomeres 1A

Synonyms

1500031H18Rik; AI851169; Pot1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110984

InnateDB Gene

IDBG-130394 (Pot1a)

Protein Structure

UniProt Annotation

Function

Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. Is a component of the double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'- TAGGGTTAG-3' sequence. Binds telomeric single-stranded sequences internally or at proximity of a 3'-end. Its activity is TERT dependent but it does not increase TERT activity (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000250}. Note=Colocalizes with telomeric DNA. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 178 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	178 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0042162	telomeric DNA binding
GO:0043047	single-stranded telomeric DNA binding

Biological Process

GO:0000723	telomere maintenance
GO:0007004	telomere maintenance via telomerase
GO:0051276	chromosome organization

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005654	nucleoplasm

Protein Structure and Domains

PDB ID

MGI:2141503

InterPro

IPR011564 Telomeric single stranded DNA binding POT1/Cdc13
IPR012340 Nucleic acid-binding, OB-fold

PFAM

PF02765

PRINTS

PIRSF

SMART

SM00976

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91WC1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

101185

UniGene

Mm.397208

RefSeq

MGI ID

MGI Symbol

Pot1a

OMIM

CCDS

HPRD

IMGT

EMBL

AK036052 AK040864 AK085041 BC016121

GenPept

AAH16121 BAC29288 BAC30723 BAC39349