Version 5.4
Mus musculus Gene: Pot1a
Summary
InnateDB Gene IDBG-130394.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pot1a
Gene Name protection of telomeres 1A
Synonyms 1500031H18Rik; AI851169; Pot1
Species Mus musculus
Ensembl Gene ENSMUSG00000029676
Encoded Proteins
IDBP-249871
protection of telomeres 1A
IDBP-249873
protection of telomeres 1A
IDBP-249875
protection of telomeres 1A
IDBP-624449
protection of telomeres 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128513:
This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:25743737-25809246
Strand Reverse strand
Band A3.1
Transcripts
ENSMUST00000115330 ENSMUSP00000110986
ENSMUST00000115329 ENSMUSP00000110984
ENSMUST00000115327 ENSMUSP00000110982
ENSMUST00000134339
ENSMUST00000156985
ENSMUST00000151186
ENSMUST00000136089
ENSMUST00000147970
ENSMUST00000166445 ENSMUSP00000131928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 178 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 178 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0042162 telomeric DNA binding
GO:0043047 single-stranded telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
GO:0007004 telomere maintenance via telomerase
GO:0051276 chromosome organization
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0000783 nuclear telomere cap complex
GO:0000784 nuclear chromosome, telomeric region
GO:0005654 nucleoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000128513
View Gene Order
Pathways
NETPATH
REACTOME
REACT_75800
Meiotic Synapsis pathway
REACT_200794
Mus musculus biological processes pathway
REACT_233453
Chromosome Maintenance pathway
REACT_188957
Cellular responses to stress pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_198626
Meiotic synapsis pathway
REACT_252672
Telomere Maintenance pathway
REACT_188804
Cell Cycle pathway
REACT_188820
Cellular Senescence pathway
REACT_226125
Packaging Of Telomere Ends pathway
REACT_198624
Meiosis pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_7963
Packaging Of Telomere Ends pathway
REACT_120956
Cellular responses to stress pathway
REACT_22172
Chromosome Maintenance pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_169274
Cellular Senescence pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt Q91WC1
TrEMBL
UniProt Splice Variant
Entrez Gene 101185
UniGene Mm.274589 Mm.397208
RefSeq NM_133931 XM_006504956
OMIM
CCDS CCDS39442
HPRD
IMGT
MGI ID MGI:2141503
MGI Symbol Pot1a
EMBL AK036052 AK040864 AK085041 BC016121
GenPept AAH16121 BAC29288 BAC30723 BAC39349
RNA Seq Atlas 101185

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca