Version 5.4
Mus musculus Protein: Cldn16
Summary
InnateDB Protein IDBP-249938.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cldn16
Protein Name claudin 16
Synonyms claudin-16; PCLN1;
Species Mus musculus
Ensembl Protein ENSMUSP00000110957
InnateDB Gene IDBG-150417 (Cldn16)
Protein Structure
UniProt Annotation
Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors (By similarity). {ECO:0000250}.
Subcellular Localization Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0042802 identical protein binding
Biological Process
GO:0006811 ion transport
GO:0016338 calcium-independent cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2148742
InterPro IPR003927 Claudin-16
IPR004031 PMP-22/EMP/MP20/Claudin superfamily
IPR006187 Claudin
PFAM PF00822
PF13903
PRINTS PR01447
PR01077
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q925N4
PhosphoSite PhosphoSite-Q925N4
TrEMBL Q14BW2
UniProt Splice Variant
Entrez Gene 114141
UniGene Mm.275205
RefSeq
MGI ID
MGI Symbol Cldn16
OMIM
CCDS CCDS28088
HPRD
IMGT
EMBL AB009016 AF323748 AK085268 AK085333 BC115574 BC115575
GenPept AAI15575 AAI15576 AAK49518 BAC39406 BAC39425 BAF80617

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca