Version 5.4
| Mus musculus Gene: Cldn16 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-150417.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Cldn16 | ||||||||
| Gene Name | claudin 16 | ||||||||
| Synonyms | claudin-16; PCLN1 | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Gene | ENSMUSG00000038148 | ||||||||
| Encoded Proteins |
claudin 16
claudin 16
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is critical for renal paracellular epithelial transport of Ca(2+) and Mg(2+) in the thick ascending loop of Henle. The gene deficiency leads to specific alterations in renal Ca(2+) and Mg(2+) balance and also to disturbances in Na(+) handling. The interaction of this gene and the Cldn 19 gene is required for their assembly into tight junctions and for renal Mg(2+) reabsorption. This gene and the Cldn1 gene are clustered on chromosome 16. [provided by RefSeq, Aug 2010] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 16:26463135-26482765 | ||||||||
| Strand | Forward strand | ||||||||
| Band | B2 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Tight junction pathway
Cell adhesion molecules (CAMs) pathway
Leukocyte transendothelial migration pathway
Hepatitis C pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH | |||||||||
| REACTOME |
Tight junction interactions pathway
Cell-Cell communication pathway
Cell junction organization pathway
Cell-cell junction organization pathway
Cell junction organization pathway
Cell-Cell communication pathway
Cell-cell junction organization pathway
Tight junction interactions pathway
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| KEGG |
Cell adhesion molecules (CAMs) pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Hepatitis C pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | Q925N4 | ||||||||
| TrEMBL | Q14BW2 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 114141 | ||||||||
| UniGene | Mm.275205 | ||||||||
| RefSeq | NM_053241 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS28088 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| MGI ID | MGI:2148742 | ||||||||
| MGI Symbol | Cldn16 | ||||||||
| EMBL | AB009016 AF323748 AK085268 AK085333 BC115574 BC115575 | ||||||||
| GenPept | AAI15575 AAI15576 AAK49518 BAC39406 BAC39425 BAF80617 | ||||||||
| RNA Seq Atlas | 114141 | ||||||||