InnateDB Protein
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IDBP-249950.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Camk2a
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Protein Name
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calcium/calmodulin-dependent protein kinase II alpha
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Synonyms
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CaMKII; mKIAA0968; R74975;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110950
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InnateDB Gene
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IDBG-150657 (Camk2a)
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Protein Structure
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Function |
CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Isoform Alpha KAP: Cytoplasm {ECO:0000305}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Postsynaptic lipid rafts. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform Alpha CaMKII is expressed in brain while isoform Alpha KAP is expressed in skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated |
Total |
27
[view]
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Protein-Protein |
26
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
37 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:88256
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InterPro |
IPR013543
Calcium/calmodulin-dependent protein kinase II, association-domain
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PFAM |
PF08332
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P11798
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PhosphoSite |
PhosphoSite-P11798
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
12322
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UniGene |
Mm.463745
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RefSeq |
NP_033922
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MGI ID |
1HKX
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MGI Symbol |
Camk2a
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OMIM |
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CCDS |
CCDS29277
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HPRD |
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IMGT |
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EMBL |
AK083245
BC031745
X14836
X87142
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GenPept |
AAH31745
BAC38829
CAA32946
CAA60620
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