InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Msrb1

Summary

InnateDB Protein

IDBP-250023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Msrb1

Protein Name

selenoprotein X 1

Synonyms

D17Wsu82e; SelR; SELX; Sepr; Sepx1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110917

InnateDB Gene

IDBG-149279 (Msrb1)

Protein Structure

UniProt Annotation

Function

Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post- translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)- sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. {ECO:0000269PubMed:14699060, ECO:0000269PubMed:23911929}.

Subcellular Localization

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0008270	zinc ion binding
GO:0033743	peptide-methionine (R)-S-oxide reductase activity
GO:0070191	methionine-R-sulfoxide reductase activity

Biological Process

GO:0006979	response to oxidative stress
GO:0030041	actin filament polymerization
GO:0030091	protein repair
GO:0045087	innate immune response
GO:0055114	oxidation-reduction process