InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnpo3

Summary

InnateDB Protein

IDBP-250040.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnpo3

Protein Name

transportin 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110906

InnateDB Gene

IDBG-132095 (Tnpo3)

Protein Structure

UniProt Annotation

Function

Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005488	binding

Biological Process

GO:0035048

splicing factor protein import into nucleus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1196412

InterPro

IPR013598 Exportin-1/Importin-beta-like
IPR016024 Armadillo-type fold

PFAM

PF08389

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6P2B1

PhosphoSite

PhosphoSite-Q6P2B1

TrEMBL

Q9CSV3

UniProt Splice Variant

Entrez Gene

320938

UniGene

Mm.276381

RefSeq

XP_006505184

MGI ID

MGI Symbol

Tnpo3

OMIM

CCDS

HPRD

IMGT

EMBL

AK011912 AK049446 AK077714 AK145723 BC052756 BC064646

GenPept

AAH52756 AAH64646 BAB27912 BAC33754 BAC36974 BAE26611