InnateDB Protein
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IDBP-250128.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Nrf1
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Protein Name
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nuclear respiratory factor 1
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Synonyms
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C87038; D6Ertd415e;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110866
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InnateDB Gene
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IDBG-132563 (Nrf1)
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Protein Structure
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Function |
Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Widely expressed in embryonic, fetal, and adult tissues.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1332235
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InterPro |
IPR019525
Nuclear respiratory factor 1, NLS/DNA-binding, dimerisation domain
IPR019526
Nuclear respiratory factor-1, activation binding domain
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PFAM |
PF10491
PF10492
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WU00
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PhosphoSite |
PhosphoSite-Q9WU00
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TrEMBL |
Q8BSP8
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UniProt Splice Variant |
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Entrez Gene |
18181
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UniGene |
Mm.412333
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RefSeq |
XP_006505070
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MGI ID |
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MGI Symbol |
Nrf1
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OMIM |
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CCDS |
CCDS19968
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HPRD |
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IMGT |
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EMBL |
AF098077
AK014494
AK029034
AK031103
CH466533
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GenPept |
AAD21938
BAB29394
BAC26256
BAC27254
EDL13755
EDL13757
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