Mus musculus Gene: Nrf1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-132563.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Nrf1 | ||||||||||||||||||||||
Gene Name | nuclear respiratory factor 1 | ||||||||||||||||||||||
Synonyms | C87038; D6Ertd415e | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000058440 | ||||||||||||||||||||||
Encoded Proteins |
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
nuclear respiratory factor 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106459:
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008] This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 6:30047988-30153458 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | A3.3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Organelle biogenesis and maintenance pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Transcriptional activation of mitochondrial biogenesis pathway
PPARA activates gene expression pathway
Mitochondrial biogenesis pathway
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KEGG |
Huntington's disease pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
PPARA activates gene expression pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Organelle biogenesis and maintenance pathway
Metabolism of lipids and lipoproteins pathway
Mitochondrial biogenesis pathway
Transcriptional activation of mitochondrial biogenesis pathway
Metabolism pathway
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KEGG |
Huntington's disease pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | D3YVX7 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 18181 | ||||||||||||||||||||||
UniGene | Mm.259258 Mm.412333 | ||||||||||||||||||||||
RefSeq | NM_001164226 NM_001164227 NM_001164228 NM_001164229 NM_001164230 NM_010938 XM_006505006 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS19968 CCDS51739 CCDS51740 CCDS51741 CCDS51742 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | MGI:1332235 | ||||||||||||||||||||||
MGI Symbol | Nrf1 | ||||||||||||||||||||||
EMBL | AC134897 AC153632 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 18181 | ||||||||||||||||||||||