InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nrf1

Summary

InnateDB Gene

IDBG-132563.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nrf1

Gene Name

nuclear respiratory factor 1

Synonyms

C87038; D6Ertd415e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058440

Encoded Proteins

IDBP-132565

nuclear respiratory factor 1

IDBP-132567

nuclear respiratory factor 1

IDBP-132569

nuclear respiratory factor 1

IDBP-250126

nuclear respiratory factor 1

IDBP-250128

nuclear respiratory factor 1

IDBP-250130

nuclear respiratory factor 1

IDBP-250132

nuclear respiratory factor 1

IDBP-250134

nuclear respiratory factor 1

IDBP-250136

nuclear respiratory factor 1

IDBP-250138

nuclear respiratory factor 1

IDBP-250140

nuclear respiratory factor 1

IDBP-536737

nuclear respiratory factor 1

IDBP-537352

nuclear respiratory factor 1

IDBP-541166

nuclear respiratory factor 1

IDBP-531779

nuclear respiratory factor 1

IDBP-625232

nuclear respiratory factor 1

IDBP-625233

nuclear respiratory factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106459:
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, Jul 2008]
This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:30047988-30153458

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000069808	ENSMUSP00000065568
ENSMUST00000069831	ENSMUSP00000067447
ENSMUST00000004761	ENSMUSP00000004761
ENSMUST00000115212	ENSMUSP00000110867
ENSMUST00000115211	ENSMUSP00000110866
ENSMUST00000115209	ENSMUSP00000110864
ENSMUST00000115208	ENSMUSP00000110863
ENSMUST00000115206	ENSMUSP00000110860
ENSMUST00000115204	ENSMUSP00000110858
ENSMUST00000115200	ENSMUSP00000110854
ENSMUST00000115199	ENSMUSP00000110853
ENSMUST00000123194	ENSMUSP00000114650
ENSMUST00000146988
ENSMUST00000133928	ENSMUSP00000117868
ENSMUST00000148990
ENSMUST00000146827	ENSMUSP00000117942
ENSMUST00000130096
ENSMUST00000133837
ENSMUST00000132866	ENSMUSP00000114451
ENSMUST00000170535	ENSMUSP00000132637
ENSMUST00000167972	ENSMUSP00000130108

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity

Biological Process

GO:0001666	response to hypoxia
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007005	mitochondrion organization
GO:0031100	organ regeneration
GO:0032355	response to estradiol
GO:0032496	response to lipopolysaccharide
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051593	response to folic acid
GO:0051602	response to electrical stimulus