InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gnptg

Summary

InnateDB Protein

IDBP-250256.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gnptg

Protein Name

N-acetylglucosamine-1-phosphotransferase, gamma subunit

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110807

InnateDB Gene

IDBG-151117 (Gnptg)

Protein Structure

UniProt Annotation

Function

Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors. {ECO:0000269PubMed:15716021}.

Subcellular Localization

Secreted. Golgi apparatus.

Disease Associations

Tissue Specificity

Widely expressed. Highly expressed in the liver, intestine, brain, thymus, testis and ovary. {ECO:0000269PubMed:15716021}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0016256	N-glycan processing to lysosome
GO:0046835	carbohydrate phosphorylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome