Version 5.4
Mus musculus Protein: Ei24
Summary
InnateDB Protein IDBP-250417.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ei24
Protein Name etoposide induced 2.4 mRNA
Synonyms AA536736; AI115355; PIG8;
Species Mus musculus
Ensembl Protein ENSMUSP00000110738
InnateDB Gene IDBG-149508 (Ei24)
Protein Structure
UniProt Annotation
Function Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269PubMed:15781622}; Multi-pass membrane protein {ECO:0000269PubMed:15781622}.
Disease Associations
Tissue Specificity Found in all the examined tissues. High expression was found in liver, skeletal muscle, pancreas, kidney heart and to a lesser extent in brain, placenta and lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006914 autophagy
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0030308 negative regulation of cell growth
GO:0042493 response to drug
GO:0050885 neuromuscular process controlling balance
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID MGI:108090
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61070
PhosphoSite PhosphoSite-Q61070
TrEMBL V9GXH2
UniProt Splice Variant
Entrez Gene 13663
UniGene Mm.488370
RefSeq NP_001186423
MGI ID
MGI Symbol Ei24
OMIM
CCDS CCDS22973
HPRD
IMGT
EMBL AC155921 AK078386 AK147776 AK159927 AK172233 FJ859041 U41751
GenPept AAC52483 ACP03809 BAC37247 BAE28130 BAE35489 BAE42899

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca