Version 5.4
Mus musculus Gene: Ei24
Summary
InnateDB Gene IDBG-149508.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ei24
Gene Name etoposide induced 2.4 mRNA
Synonyms AA536736; AI115355; PIG8
Species Mus musculus
Ensembl Gene ENSMUSG00000062762
Encoded Proteins
IDBP-250417
etoposide induced 2.4 mRNA
IDBP-624076
etoposide induced 2.4 mRNA
IDBP-788978
etoposide induced 2.4 mRNA
IDBP-788979
etoposide induced 2.4 mRNA
IDBP-788980
etoposide induced 2.4 mRNA
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000149547:
This gene has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:36779159-36797361
Strand Reverse strand
Band A4
Transcripts
ENSMUST00000115086 ENSMUSP00000110738
ENSMUST00000163192 ENSMUSP00000132270
ENSMUST00000185124
ENSMUST00000183422
ENSMUST00000183430
ENSMUST00000184395 ENSMUSP00000139150
ENSMUST00000184235 ENSMUSP00000139319
ENSMUST00000183360 ENSMUSP00000139235
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006914 autophagy
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0030308 negative regulation of cell growth
GO:0042493 response to drug
GO:0050885 neuromuscular process controlling balance
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000149547
View Gene Order
ENSBTAG00000007202
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04115
p53 signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04115
p53 signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q61070
TrEMBL C3VDI2 Q8C5G8 V9GXH2
UniProt Splice Variant
Entrez Gene 13663
UniGene Mm.411130 Mm.4337 Mm.488370
RefSeq NM_007915 NM_001199494
OMIM
CCDS CCDS22973
HPRD
IMGT
MGI ID MGI:108090
MGI Symbol Ei24
EMBL AC155921 AK078386 AK147776 AK159927 AK172233 FJ859041 U41751
GenPept AAC52483 ACP03809 BAC37247 BAE28130 BAE35489 BAE42899
RNA Seq Atlas 13663

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca