InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHRNB4

Summary

InnateDB Protein

IDBP-25049.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHRNB4

Protein Name

cholinergic receptor, nicotinic, beta 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261751

InnateDB Gene

IDBG-25047 (CHRNB4)

Protein Structure

UniProt Annotation

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004889	acetylcholine-activated cation-selective channel activity
GO:0005230	extracellular ligand-gated ion channel activity
GO:0015276	ligand-gated ion channel activity
GO:0015464	acetylcholine receptor activity

Biological Process

GO:0001508	action potential
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0006939	smooth muscle contraction
GO:0006940	regulation of smooth muscle contraction
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007271	synaptic transmission, cholinergic
GO:0007626	locomotory behavior
GO:0034220	ion transmembrane transport
GO:0035094	response to nicotine
GO:0035095	behavioral response to nicotine
GO:0042391	regulation of membrane potential
GO:0046928	regulation of neurotransmitter secretion
GO:0060084	synaptic transmission involved in micturition

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005892	acetylcholine-gated channel complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR002394 Nicotinic acetylcholine receptor
IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
IPR006201 Neurotransmitter-gated ion-channel
IPR006202 Neurotransmitter-gated ion-channel ligand-binding

PFAM

PF02932
PF02931

PRINTS

PR00254
PR00252

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P30926