InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kalrn

Summary

InnateDB Protein

IDBP-250543.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Kalrn

Protein Name

kalirin, RhoGEF kinase

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110624

InnateDB Gene

IDBG-155984 (Kalrn)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0032319	regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction

Cellular Component

Protein Structure and Domains

PDB ID

MGI:2685385

InterPro

IPR000219 Dbl homology (DH) domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM