Version 5.4
Mus musculus Protein: Kalrn
Summary
InnateDB Protein IDBP-250555.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kalrn
Protein Name kalirin, RhoGEF kinase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000110611
InnateDB Gene IDBG-155984 (Kalrn)
Protein Structure
UniProt Annotation
Function Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity). {ECO:0000250UniProtKB:P97924}.
Subcellular Localization Cytoplasm {ECO:0000250UniProtKB:O60229, ECO:0000250UniProtKB:P97924}. Cytoplasm, cytoskeleton {ECO:0000250UniProtKB:O60229, ECO:0000250UniProtKB:P97924}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004674 protein serine/threonine kinase activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006468 protein phosphorylation
GO:0032319 regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2685385
InterPro IPR000219 Dbl homology (DH) domain
IPR001251 CRAL-TRIO domain
IPR001849 Pleckstrin homology domain
IPR002017 Spectrin repeat
IPR018159 Spectrin/alpha-actinin
PFAM PF00621
PF00650
PF13716
PF00169
PF00435
PRINTS
PIRSF
SMART SM00325
SM00516
SM00233
SM00150
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2CG49
PhosphoSite PhosphoSite-A2CG49
TrEMBL D3Z559
UniProt Splice Variant
Entrez Gene 545156
UniGene Mm.82274
RefSeq NP_001157740
MGI ID 1WFW
MGI Symbol Kalrn
OMIM
CCDS CCDS49836
HPRD
IMGT
EMBL AC154524 AC154588 AC155257 AC165079 AK008844 AK081504 AK088732 AK139581 AK158544 AK159031 BC157950 BC172101 CT010573
GenPept AAI57951 AAI72101 BAB25925 BAC38239 BAC40535 BAE24075 BAE34552 BAE34776 CAM18305 CAM18306 CAM18307 CAM18308 CAM18309

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca