InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sema4c

Summary

InnateDB Protein

IDBP-250638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sema4c

Protein Name

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

Synonyms

AI426163; mKIAA1739; Semacl1; Semaf; Semai;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110643

InnateDB Gene

IDBG-144779 (Sema4c)

Protein Structure

UniProt Annotation

Function

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress- activated MAPK cascade. {ECO:0000269PubMed:15811348, ECO:0000269PubMed:17498836, ECO:0000269PubMed:17554007, ECO:0000269PubMed:21122816}.

Subcellular Localization

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269PubMed:11134026}; Single-pass type I membrane protein {ECO:0000269PubMed:11134026}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269PubMed:11134026}; Single-pass type I membrane protein {ECO:0000269PubMed:11134026}.

Disease Associations

Tissue Specificity

Predominantly expressed in brain (at protein level). {ECO:0000269PubMed:11134026}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0001843	neural tube closure
GO:0007275	multicellular organismal development
GO:0021535	cell migration in hindbrain
GO:0021549	cerebellum development
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0042692	muscle cell differentiation
GO:0071526	semaphorin-plexin signaling pathway

Cellular Component

GO:0005615	extracellular space
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0045211	postsynaptic membrane