InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mbd2

Summary

InnateDB Protein

IDBP-250694.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mbd2

Protein Name

methyl-CpG binding domain protein 2

Synonyms

MBD2a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110596

InnateDB Gene

IDBG-157229 (Mbd2)

Protein Structure

UniProt Annotation

Function

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity). May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity). Selectively represses transcription activity of methylated rRNA promoters. {ECO:0000250, ECO:0000269PubMed:14610093, ECO:0000269PubMed:9774669}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain, heart, kidney, lung, skeletal muscle, spleen and testis. Detected at lower levels in embryonic stem cells. {ECO:0000269PubMed:9774669}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003729	mRNA binding
GO:0008327	methyl-CpG binding
GO:0035197	siRNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030177	positive regulation of Wnt signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042711	maternal behavior
GO:0043623	cellular protein complex assembly