InnateDB Protein
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IDBP-250723.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Celf2
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Protein Name
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CUGBP, Elav-like family member 2
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Synonyms
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B230218O03; B230345P09Rik; C88023; CELF-2; CUG-BP2; Cugbp2; D230046B21Rik; Etr-3; mETR-3; Napor; Napor-2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110584
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InnateDB Gene
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IDBG-135132 (Celf2)
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Protein Structure
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Function |
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing (By similarity). Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle (By similarity). Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB (By similarity). Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs (By similarity). Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA (By similarity). Involved in the apoB RNA editing activity (By similarity). Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury. Modulates the cellular apoptosis program by regulating COX2-mediated prostaglandin E2 (PGE2) expression. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK (By similarity). Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the TNNT2 alternative exon 5 (By similarity). Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs (By similarity). Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine (By similarity). Binds AU-rich sequences in the 3'-UTR of COX2 mRNA. Binds to an intronic RNA element responsible for the silencing of exon 21 splicing. Binds to (CUG)n repeats. {ECO:0000250, ECO:0000269PubMed:12022233, ECO:0000269PubMed:12535526, ECO:0000269PubMed:15358864}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Colocalizes with APOBEC1 and A1CF (By similarity). RNA-binding activity is detected in both nuclear and cytoplasmic compartments (By similarity). Accumulates in the cytoplasm after ionizing radiation. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in tongue, spleen and brain (at protein level). Expressed in liver, thigh, stomach, lung and heart to very low levels (at protein level). Expressed in heart, brain, lung and muscle. {ECO:0000269PubMed:10524244, ECO:0000269PubMed:11158314, ECO:0000269PubMed:15358864, ECO:0000269PubMed:15830352}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1338822
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z0H4
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PhosphoSite |
PhosphoSite-Q9Z0H4
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TrEMBL |
S4R2U1
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UniProt Splice Variant |
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Entrez Gene |
14007
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UniGene |
Mm.473989
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RefSeq |
XP_006497393
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MGI ID |
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MGI Symbol |
Celf2
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OMIM |
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CCDS |
CCDS50494
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HPRD |
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IMGT |
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EMBL |
AF090696
AF090697
AK137292
AK151818
AK152628
AK153267
AK160861
AK161349
AK164914
AL772190
AL840637
AL845485
AL845492
AL845515
AL929240
BC026856
BX649227
CR936244
CU207293
Y18298
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GenPept |
AAD13763
AAD13764
AAH26856
BAE23295
BAE30715
BAE31371
BAE31857
BAE36053
BAE36341
BAE37963
CAA77110
CAM18466
CAM18813
CAM18816
CAM18817
CAM18818
CAM46032
CAM46034
CAM46035
CAM46036
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