InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pacsin1

Summary

InnateDB Protein

IDBP-250855.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pacsin1

Protein Name

protein kinase C and casein kinase substrate in neurons 1

Synonyms

A830061D09Rik; H74; mKIAA1379; syndapin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110523

InnateDB Gene

IDBG-157012 (Pacsin1)

Protein Structure

UniProt Annotation

Function

Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. {ECO:0000269PubMed:11082044, ECO:0000269PubMed:20404169, ECO:0000269PubMed:21926968, ECO:0000269PubMed:23035120}.

Subcellular Localization

Cytoplasm. Cell projection {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse. Cytoplasm, cytosol. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Colocalizes with MAPT in axons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in brain. Detected in hippocampus and dorsal root ganglion neurons. Detected in rod photoreceptor terminals in the outer plexiform layer of the retina (at protein level). In CNS neurons, high levels in the pyramidal cells of the hippocampus, Purkinje cells of the cerebellum and large neurons of the cortex and brain stem. {ECO:0000269PubMed:11082044, ECO:0000269PubMed:21926968, ECO:0000269PubMed:23035120, ECO:0000269PubMed:9746365}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008092	cytoskeletal protein binding

Biological Process

GO:0007015	actin filament organization
GO:0007165	signal transduction
GO:0045087	innate immune response (InnateDB)
GO:0045806	negative regulation of endocytosis
GO:0048488	synaptic vesicle endocytosis
GO:0048812	neuron projection morphogenesis
GO:0072657	protein localization to membrane
GO:0097320	membrane tubulation

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0030054	cell junction
GO:0030137	COPI-coated vesicle
GO:0030659	cytoplasmic vesicle membrane
GO:0032587	ruffle membrane
GO:0043679	axon terminus
GO:0045202	synapse