Version 5.4
Mus musculus Gene: Pacsin1
Summary
InnateDB Gene IDBG-157012.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pacsin1
Gene Name protein kinase C and casein kinase substrate in neurons 1
Synonyms A830061D09Rik; H74; mKIAA1379; syndapin
Species Mus musculus
Ensembl Gene ENSMUSG00000040276
Encoded Proteins
IDBP-157014
protein kinase C and casein kinase substrate in neurons 1
IDBP-157016
protein kinase C and casein kinase substrate in neurons 1
IDBP-250855
protein kinase C and casein kinase substrate in neurons 1
IDBP-250857
protein kinase C and casein kinase substrate in neurons 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22488361
Pacsin1 regulates the Tlr7/9-mediated type I interferon response in plasmacytoid dendritic cells.
InnateDB Annotation from Orthologs
Summary
PMID 22488361
[Homo sapiens] PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124507:
Gene Information
Type Protein coding
Genomic Location Chromosome 17:27655509-27711106
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000045896 ENSMUSP00000044168
ENSMUST00000097360 ENSMUSP00000094973
ENSMUST00000114873 ENSMUSP00000110523
ENSMUST00000114872 ENSMUSP00000110522
ENSMUST00000155259
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0007015 actin filament organization
GO:0007165 signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0045806 negative regulation of endocytosis
GO:0048488 synaptic vesicle endocytosis
GO:0048812 neuron projection morphogenesis
GO:0072657 protein localization to membrane
GO:0097320 membrane tubulation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030054 cell junction
GO:0030137 COPI-coated vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0032587 ruffle membrane
GO:0043679 axon terminus
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124507
View Gene Order
ENSBTAG00000016124
Not yet available
Cross-References
SwissProt Q61644
TrEMBL Q543Y7
UniProt Splice Variant
Entrez Gene 23969
UniGene Mm.4926
RefSeq NM_001286743 NM_001286744 NM_011861 XM_006524226 XM_006536750 NM_178365
OMIM
CCDS CCDS28567
HPRD
IMGT
MGI ID MGI:1345181
MGI Symbol Pacsin1
EMBL AK043967 BC014698 X85124
GenPept AAH14698 BAC31717 CAA59437
RNA Seq Atlas 23969

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca