InnateDB Protein
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IDBP-250915.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dnajb6
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Protein Name
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DnaJ (Hsp40) homolog, subfamily B, member 6
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Synonyms
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mDj4; Mrj;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110488
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InnateDB Gene
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IDBG-144785 (Dnajb6)
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Protein Structure
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Function |
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins (By similarity). Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
37 [view]
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Molecular Function |
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Biological Process |
GO:0006457
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protein folding
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GO:0030036
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actin cytoskeleton organization
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GO:0030198
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extracellular matrix organization
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GO:0032781
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positive regulation of ATPase activity
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GO:0034504
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protein localization to nucleus
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GO:0043154
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0045109
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intermediate filament organization
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0060710
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chorio-allantoic fusion
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GO:0060715
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syncytiotrophoblast cell differentiation involved in labyrinthine layer development
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GO:0060717
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chorion development
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Cellular Component |
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PDB ID |
MGI:1344381
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InterPro |
IPR001623
DnaJ domain
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PFAM |
PF00226
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PRINTS |
PR00625
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PIRSF |
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SMART |
SM00271
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TIGRFAMs |
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Modification |
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SwissProt |
O54946
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PhosphoSite |
PhosphoSite-O54946
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
23950
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UniGene |
Mm.483283
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RefSeq |
NP_035977
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MGI ID |
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MGI Symbol |
Dnajb6
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OMIM |
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CCDS |
CCDS39043
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HPRD |
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IMGT |
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EMBL |
AB028854
AF035962
AK133805
AK134387
AK144182
AK151219
AK151752
AK152626
AK152632
AK153091
AK169332
AK169767
BC003702
BC083349
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GenPept |
AAC16759
AAH03702
AAH83349
BAA88302
BAE21853
BAE22124
BAE25752
BAE30213
BAE30661
BAE31369
BAE31375
BAE31714
BAE41085
BAE41354
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