InnateDB Protein
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IDBP-250933.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Il15ra
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Protein Name
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interleukin 15 receptor, alpha chain
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Synonyms
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AA690181; IL-15RA;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110483
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InnateDB Gene
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IDBG-136731 (Il15ra)
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Protein Structure
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Function |
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Signal transduction involves SYK (By similarity). {ECO:0000250}.
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Subcellular Localization |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:12885940, ECO:0000269PubMed:7641685}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
GO:0007259
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JAK-STAT cascade
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GO:0010977
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negative regulation of neuron projection development
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GO:0031667
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response to nutrient levels
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GO:0032825
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positive regulation of natural killer cell differentiation
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Cellular Component |
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PDB ID |
MGI:104644
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InterPro |
IPR000436
Sushi/SCR/CCP
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PFAM |
PF00084
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PRINTS |
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PIRSF |
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SMART |
SM00032
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TIGRFAMs |
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Modification |
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SwissProt |
Q60819
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q80SW0
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UniProt Splice Variant |
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Entrez Gene |
16169
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UniGene |
Mm.200196
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RefSeq |
NP_001258429
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MGI ID |
2PSM
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MGI Symbol |
Il15ra
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OMIM |
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CCDS |
CCDS70978
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HPRD |
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IMGT |
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EMBL |
AL831794
AY219715
AY219716
AY219717
AY221616
AY221617
AY221618
BC022705
CH466542
U22339
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GenPept |
AAC52240
AAH22705
AAO62310
AAO62311
AAO62312
AAO74882
AAO74883
AAO74884
CAM13743
CAM13744
CAM13745
EDL08021
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