Version 5.4
Mus musculus Protein: Il15ra
Summary
InnateDB Protein IDBP-250937.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il15ra
Protein Name interleukin 15 receptor, alpha chain
Synonyms AA690181; IL-15RA;
Species Mus musculus
Ensembl Protein ENSMUSP00000110481
InnateDB Gene IDBG-136731 (Il15ra)
Protein Structure
UniProt Annotation
Function High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Signal transduction involves SYK (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12885940, ECO:0000269PubMed:7641685}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007259 JAK-STAT cascade
GO:0010977 negative regulation of neuron projection development
GO:0031667 response to nutrient levels
GO:0032825 positive regulation of natural killer cell differentiation
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031410 cytoplasmic vesicle
GO:0031965 nuclear membrane
Protein Structure and Domains
PDB ID MGI:104644
InterPro IPR000436 Sushi/SCR/CCP
PFAM PF00084
PRINTS
PIRSF
SMART SM00032
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q60819
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 16169
UniGene Mm.200196
RefSeq
MGI ID 2PSM
MGI Symbol Il15ra
OMIM
CCDS
HPRD
IMGT
EMBL AL831794 AY219715 AY219716 AY219717 AY221616 BC022705 U22339
GenPept AAC52240 AAH22705 AAO62310 AAO62311 AAO62312 AAO74882 CAM13743 CAM13744 CAM13745

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca