InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atp5a1

Summary

InnateDB Protein

IDBP-251086.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Atp5a1

Protein Name

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1

Synonyms

AI035633; AL022851; AL023067; Atpm; D18Ertd206e; Mom2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110396

InnateDB Gene

IDBG-160170 (Atp5a1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0042288	MHC class I protein binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006200	ATP catabolic process
GO:0006629	lipid metabolic process
GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0046034	ATP metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)

Protein Structure and Domains

PDB ID

MGI:88115

InterPro

IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal
IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain
IPR005294 ATPase, F1 complex, alpha subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00006
PF00306
PF02874

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-