InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gsk3b

Summary

InnateDB Protein

IDBP-251115.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Gsk3b

Protein Name

glycogen synthase kinase 3 beta

Synonyms

7330414F15Rik; 8430431H08Rik; C86142; GSK-3; GSK-3beta; GSK3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110398

InnateDB Gene

IDBG-159859 (Gsk3b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 244 interaction(s) predicted by orthology.

Experimentally validated
Total	57 [view]
Protein-Protein	57 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	244 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008013	beta-catenin binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050321	tau-protein kinase activity

Biological Process

GO:0000320	re-entry into mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006611	protein export from nucleus
GO:0006983	ER overload response
GO:0007409	axonogenesis
GO:0007520	myoblast fusion
GO:0008283	cell proliferation
GO:0009887	organ morphogenesis
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0010977	negative regulation of neuron projection development
GO:0014043	negative regulation of neuron maturation
GO:0014902	myotube differentiation
GO:0016055	Wnt signaling pathway
GO:0016477	cell migration
GO:0018105	peptidyl-serine phosphorylation
GO:0032092	positive regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035372	protein localization to microtubule
GO:0035556	intracellular signal transduction
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045444	fat cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060070	canonical Wnt signaling pathway
GO:2000738	positive regulation of stem cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0030426	growth cone
GO:0030529	ribonucleoprotein complex
GO:0030877	beta-catenin destruction complex
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0043227	membrane-bounded organelle
GO:0044297	cell body

Protein Structure and Domains

PDB ID

MGI:1861437

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt