InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbmx

Summary

InnateDB Protein

IDBP-251149.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbmx

Protein Name

RNA binding motif protein, X chromosome

Synonyms

hnRNP G;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110378

InnateDB Gene

IDBG-147639 (Rbmx)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single- stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Plays also a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1- beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269PubMed:17188681, ECO:0000269PubMed:19403048}.

Subcellular Localization

Nucleus. Note=Localizes in numerous small granules in the nucleus (By similarity). Component of ribonucleosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Both isoforms are widely expressed. {ECO:0000269PubMed:10391207}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 75 interaction(s) predicted by orthology.