InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ABCB1

Summary

InnateDB Protein

IDBP-25116.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCB1

Protein Name

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Synonyms

ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1;

Species

Homo sapiens

Ensembl Protein

ENSP00000265724

InnateDB Gene

IDBG-25114 (ABCB1)

Protein Structure

UniProt Annotation

Function

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000255PROSITE-ProRule:PRU00441}.

Disease Associations

Inflammatory bowel disease 13 (IBD13) [MIM:612244]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Expressed in liver, kidney, small intestine and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008559	xenobiotic-transporting ATPase activity
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0042493	response to drug
GO:0042908	xenobiotic transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0072089	stem cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001140 ABC transporter, transmembrane domain
IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR019195 ABC transporter, ATPase, putative
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00664
PF13748
PF00005
PF09818

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P08183