InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ABCB1

Summary

InnateDB Gene

IDBG-25114.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ABCB1

Gene Name

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Synonyms

ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1

Species

Homo sapiens

Ensembl Gene

ENSG00000085563

Encoded Proteins

IDBP-25116

ATP-binding cassette, sub-family B (MDR/TAP), member 1

IDBP-380981

ATP-binding cassette, sub-family B (MDR/TAP), member 1

IDBP-590717

ATP-binding cassette, sub-family B (MDR/TAP), member 1

IDBP-807489

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:87503633-87713323

Strand

Reverse strand

Band

q21.12

Transcripts

ENST00000265724	ENSP00000265724
ENST00000416177	ENSP00000399419
ENST00000488737
ENST00000491360
ENST00000475929
ENST00000496821
ENST00000483831
ENST00000482527
ENST00000476862
ENST00000543898	ENSP00000444095
ENST00000622132	ENSP00000478255

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008559	xenobiotic-transporting ATPase activity
GO:0016887	ATPase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006855	drug transmembrane transport
GO:0042493	response to drug
GO:0042908	xenobiotic transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0072089	stem cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040584

View Gene Order

ENSBTAG00000005997

Not yet available

Pathways

NETPATH

REACTOME

REACT_15480

ABC-family proteins mediated transport pathway

REACT_120801

Abacavir transmembrane transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_121189

Abacavir transport and metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa02010

ABC transporters pathway

hsa04976

Bile secretion pathway

INOH

PID NCI

hif1_tfpathway

HIF-1-alpha transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.489033

RefSeq

NM_000927

HUGO

OMIM

CCDS

CCDS5608

HPRD

01370

IMGT

EMBL

GenPept

RNA Seq Atlas