Version 5.4
| Mus musculus Protein: Arhgap21 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-251428.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Arhgap21 | ||||||
| Protein Name | Rho GTPase activating protein 21 | ||||||
| Synonyms | 5530401C11Rik; AA416458; ARHGAP10; | ||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000110241 | ||||||
| InnateDB Gene | IDBG-140571 (Arhgap21) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). {ECO:0000250}. | ||||||
| Subcellular Localization | Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localization to the Golgi is dependent on interaction with GTP-bound ARF1. {ECO:0000250}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | |||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:1918685 | ||||||
| InterPro |
IPR000198
Rho GTPase-activating protein domain IPR001478 PDZ domain IPR001849 Pleckstrin homology domain IPR008936 Rho GTPase activation protein |
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| PFAM |
PF00620
PF00595 PF13180 PF00169 |
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00324
SM00228 SM00233 |
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | |||||||
| PhosphoSite | PhosphoSite-Q6DFV3 | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 71435 | ||||||
| UniGene | Mm.483341 | ||||||
| RefSeq | XP_006497602 | ||||||
| MGI ID | |||||||
| MGI Symbol | Arhgap21 | ||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | |||||||
| GenPept | |||||||