Version 5.4
Mus musculus Gene: Arhgap21
Summary
InnateDB Gene IDBG-140571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap21
Gene Name Rho GTPase activating protein 21
Synonyms 5530401C11Rik; AA416458; ARHGAP10
Species Mus musculus
Ensembl Gene ENSMUSG00000036591
Encoded Proteins
IDBP-251428
Rho GTPase activating protein 21
IDBP-539044
Rho GTPase activating protein 21
IDBP-541391
Rho GTPase activating protein 21
IDBP-537745
Rho GTPase activating protein 21
IDBP-533477
Rho GTPase activating protein 21
IDBP-626827
Rho GTPase activating protein 21
IDBP-626828
Rho GTPase activating protein 21
IDBP-626833
Rho GTPase activating protein 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107863:
ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:20847919-20968881
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000114594 ENSMUSP00000110241
ENSMUST00000141298 ENSMUSP00000120357
ENSMUST00000154230 ENSMUSP00000122497
ENSMUST00000131542
ENSMUST00000143491
ENSMUST00000127512
ENSMUST00000136241
ENSMUST00000154657
ENSMUST00000156142
ENSMUST00000140230 ENSMUSP00000122271
ENSMUST00000125783 ENSMUSP00000123403
ENSMUST00000131394
ENSMUST00000173194 ENSMUSP00000133851
ENSMUST00000174584 ENSMUSP00000133347
ENSMUST00000174825
ENSMUST00000173784 ENSMUSP00000133539
ENSMUST00000173566
ENSMUST00000173654
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
Biological Process
GO:0007030 Golgi organization
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity
GO:0051683 establishment of Golgi localization
GO:0051684 maintenance of Golgi location
GO:0072384 organelle transport along microtubule
Cellular Component
GO:0005622 intracellular
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107863
View Gene Order
ENSBTAG00000021857
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28507 Mm.397962 Mm.465492 Mm.483341
RefSeq NM_001081364 NM_001128084 XM_006497538 XM_006497539 XM_006497540 XM_006497541 XM_006497542 XM_006497543 XM_006497544 XM_006497545
OMIM
CCDS CCDS38054 CCDS50512
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca