InnateDB Protein
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IDBP-251610.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Gls
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Protein Name
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glutaminase
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Synonyms
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6330442B14; AI314027; B230365M23Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110155
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InnateDB Gene
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IDBG-153335 (Gls)
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Protein Structure
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Function |
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. {ECO:0000269PubMed:16641247, ECO:0000269PubMed:22228304, ECO:0000269PubMed:22373647}.
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Subcellular Localization |
Isoform 1: Cytoplasm, cytosol {ECO:0000250}.Isoform 2: Mitochondrion.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:95752
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InterPro |
IPR012338
Beta-lactamase/transpeptidase-like
IPR015868
Glutaminase
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PFAM |
PF04960
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
D3Z7P3
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PhosphoSite |
PhosphoSite-D3Z7P3
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
14660
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UniGene |
Mm.487152
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RefSeq |
NP_001106854
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MGI ID |
4JKT
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MGI Symbol |
Gls
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OMIM |
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CCDS |
CCDS48256
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HPRD |
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IMGT |
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EMBL |
AC123752
AK173039
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GenPept |
BAD32317
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