InnateDB Protein
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IDBP-251736.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pglyrp2
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Protein Name
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peptidoglycan recognition protein 2
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Synonyms
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C730002N09Rik; Pglyrpl; PGRP-L; tagL;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000110099
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InnateDB Gene
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IDBG-251732 (Pglyrp2)
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Protein Structure
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Function |
May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.
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Subcellular Localization |
Secreted. Membrane.
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Disease Associations |
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Tissue Specificity |
Strongly expressed in liver and fetal liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
GO:0002221
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pattern recognition receptor signaling pathway
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GO:0009253
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peptidoglycan catabolic process
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GO:0016045
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detection of bacterium
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GO:0032689
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negative regulation of interferon-gamma production
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GO:0032827
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negative regulation of natural killer cell differentiation involved in immune response
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GO:0044117
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growth of symbiont in host
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GO:0045087
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innate immune response (InnateDB)
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GO:0050727
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regulation of inflammatory response
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GO:0050830
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defense response to Gram-positive bacterium
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Cellular Component |
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PDB ID |
MGI:1928099
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InterPro |
IPR002502
N-acetylmuramoyl-L-alanine amidase domain
IPR006619
Peptidoglycan recognition protein family domain, metazoa/bacteria
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PFAM |
PF01510
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PRINTS |
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PIRSF |
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SMART |
SM00644
SM00701
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TIGRFAMs |
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Modification |
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SwissProt |
Q8VCS0
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q54A77
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UniProt Splice Variant |
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Entrez Gene |
57757
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UniGene |
Mm.86752
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RefSeq |
NP_001258407
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MGI ID |
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MGI Symbol |
Pglyrp2
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OMIM |
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CCDS |
CCDS37557
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HPRD |
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IMGT |
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EMBL |
AB084140
AF149837
AF149838
AF392055
AY282722
BC019396
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GenPept |
AAF22233
AAF22234
AAH19396
AAM73674
AAP22283
BAC99304
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