Version 5.4
Mus musculus Gene: Pglyrp2
Summary
InnateDB Gene IDBG-251732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pglyrp2
Gene Name peptidoglycan recognition protein 2
Synonyms C730002N09Rik; Pglyrpl; PGRP-L; tagL
Species Mus musculus
Ensembl Gene ENSMUSG00000079563
Encoded Proteins
IDBP-251736
peptidoglycan recognition protein 2
IDBP-626264
peptidoglycan recognition protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21439073
Pglyrp2 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.
InnateDB Annotation from Orthologs
Summary
PMID 20418257
[Homo sapiens] PGLYRP2 is a secreted innate immunity protein that is expressed in the liver and is conserved from insects to mammals, it recognizes bacterial peptidoglycan, and functions in antibacterial immunity and inflammation.
PMID 21439073
[Homo sapiens] PGLYRP2 is a member of the Peptidoglycan Recognition Proteins (PGRP) family and recognizes peptidoglycan, a structural component of bacterial cell walls, as a part of innate immune response against infections.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161031:
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:32413100-32424167
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000114455 ENSMUSP00000110099
ENSMUST00000170392 ENSMUSP00000129964
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016019 peptidoglycan receptor activity
GO:0042834 peptidoglycan binding
Biological Process
GO:0002221 pattern recognition receptor signaling pathway
GO:0009253 peptidoglycan catabolic process
GO:0016045 detection of bacterium
GO:0032689 negative regulation of interferon-gamma production
GO:0032827 negative regulation of natural killer cell differentiation involved in immune response
GO:0044117 growth of symbiont in host
GO:0045087 innate immune response (InnateDB)
GO:0050727 regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000161031
View Gene Order
ENSBTAG00000012280
Not yet available
Cross-References
SwissProt Q8VCS0
TrEMBL Q54A77
UniProt Splice Variant
Entrez Gene 57757
UniGene Mm.486741 Mm.86752
RefSeq NM_001271476 NM_021319 XM_006524714 XM_006524711
OMIM
CCDS CCDS37557
HPRD
IMGT
MGI ID MGI:1928099
MGI Symbol Pglyrp2
EMBL AB084140 AF149837 AF149838 AF392055 AY282722 BC019396
GenPept AAF22233 AAF22234 AAH19396 AAM73674 AAP22283 BAC99304
RNA Seq Atlas 57757

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca