InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Snx10

Summary

InnateDB Protein

IDBP-251757.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Snx10

Protein Name

sorting nexin 10

Synonyms

2410004M09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110082

InnateDB Gene

IDBG-147521 (Snx10)

Protein Structure

UniProt Annotation

Function

Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption. {ECO:0000269PubMed:22174188}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:22174188}. Endosome membrane {ECO:0000269PubMed:22174188}; Peripheral membrane protein {ECO:0000269PubMed:22174188}; Cytoplasmic side {ECO:0000269PubMed:22174188}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=May also localize to nucleus and endoplasmic reticulum.

Disease Associations

Tissue Specificity

Expressed in femur, calvariae and teeth. {ECO:0000269PubMed:22174188}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	0
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005545	1-phosphatidylinositol binding
GO:0035091	phosphatidylinositol binding
GO:0051117	ATPase binding

Biological Process

GO:0006886	intracellular protein transport
GO:0007032	endosome organization
GO:0030316	osteoclast differentiation
GO:0042384	cilium assembly
GO:0061512	protein localization to cilium
GO:0071539	protein localization to centrosome