Version 5.4
Mus musculus Protein: Hoxa9
Summary
InnateDB Protein IDBP-251798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hoxa9
Protein Name homeobox A9
Synonyms D6a9; Hox-1.7;
Species Mus musculus
Ensembl Protein ENSMUSP00000110068
InnateDB Gene IDBG-148014 (Hoxa9)
Protein Structure
UniProt Annotation
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Expressed in high level in the embryonic and adult spinal cord with a preference in the posterior region.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 17 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0008584 male gonad development
GO:0009952 anterior/posterior pattern specification
GO:0009954 proximal/distal pattern formation
GO:0010468 regulation of gene expression
GO:0030879 mammary gland development
GO:0035115 embryonic forelimb morphogenesis
GO:0045638 negative regulation of myeloid cell differentiation
GO:0048706 embryonic skeletal system development
GO:0060065 uterus development
GO:0060216 definitive hemopoiesis
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:96180
InterPro IPR006711 Hox9, N-terminal activation domain
PFAM PF04617
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P09631
PhosphoSite PhosphoSite-P09631
TrEMBL
UniProt Splice Variant
Entrez Gene 15405
UniGene Mm.4694
RefSeq
MGI ID 1PUF
MGI Symbol Hoxa9
OMIM
CCDS
HPRD
IMGT
EMBL AB005457 AB005458 AB008914 BC055059 M28449
GenPept AAA78790 AAH55059 BAA25800 BAA25801 BAA25802

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca