InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab11b

Summary

InnateDB Protein

IDBP-251892.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab11b

Protein Name

RAB11B, member RAS oncogene family

Synonyms

A730055L17Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000110021

InnateDB Gene

IDBG-225619 (Rab11b)

Protein Structure

UniProt Annotation

Function

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage- gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. {ECO:0000269PubMed:10942597, ECO:0000269PubMed:19335615, ECO:0000269PubMed:21291502, ECO:0000269PubMed:22129970}.

Subcellular Localization

Recycling endosome membrane {ECO:0000305PubMed:10942597}; Lipid-anchor {ECO:0000305PubMed:10942597}; Cytoplasmic side {ECO:0000305PubMed:10942597}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Recruited to phagosomes containing S.aureus. {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundantly expressed in brain, heart and testis. Also detected in kidney and pancreatic islets. {ECO:0000269PubMed:19335615}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0001881	receptor recycling
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0032402	melanosome transport
GO:0033572	transferrin transport
GO:0035773	insulin secretion involved in cellular response to glucose stimulus
GO:0044070	regulation of anion transport
GO:0045054	constitutive secretory pathway
GO:0045055	regulated secretory pathway
GO:0071468	cellular response to acidity
GO:1990126	retrograde transport, endosome to plasma membrane
GO:2000008	regulation of protein localization to cell surface
GO:2001135	regulation of endocytic recycling

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0030670	phagocytic vesicle membrane
GO:0030672	synaptic vesicle membrane
GO:0045335	phagocytic vesicle
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:99425

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt