Mus musculus Protein: Noxa1 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-251901.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Noxa1 | ||||||||||
Protein Name | NADPH oxidase activator 1 | ||||||||||
Synonyms | |||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000110014 | ||||||||||
InnateDB Gene | IDBG-144012 (Noxa1) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. {ECO:0000269PubMed:12473664, ECO:0000269PubMed:15326186, ECO:0000269PubMed:16814099}. | ||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:16814099}. Cell membrane {ECO:0000269PubMed:16814099}. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | Widely expressed with a tissue distribution similar to the one of NOX1. Detected in colon, uterus, prostate, small intestine, stomach, lung, thyroid, aorta, inner ear and salivary glands. Expressed in colon, small intestine and aortic smooth muscle cells (at protein level). {ECO:0000269PubMed:12473664, ECO:0000269PubMed:12657628, ECO:0000269PubMed:15949904, ECO:0000269PubMed:16814099}. | ||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:2449980 | ||||||||||
InterPro |
IPR000270
Phox/Bem1p IPR001452 SH3 domain IPR011511 Variant SH3 domain IPR013026 Tetratricopeptide repeat-containing domain IPR019734 Tetratricopeptide repeat |
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PFAM |
PF00564
PF00018 PF14604 PF07653 PF13174 PF13176 PF13181 |
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PRINTS |
PR00452
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PIRSF | |||||||||||
SMART |
SM00666
SM00326 SM00028 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | Q8CJ00 | ||||||||||
PhosphoSite | PhosphoSite-Q8CJ00 | ||||||||||
TrEMBL | |||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 241275 | ||||||||||
UniGene | Mm.218774 | ||||||||||
RefSeq | NP_001157098 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Noxa1 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS50524 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AF539798 AK087263 AL732585 AY255770 BC047532 | ||||||||||
GenPept | AAH47532 AAN75143 AAP13481 BAC39832 CAM17999 CAM18000 | ||||||||||